Benadryl for Dogs – Is It Safe?

Dogs get allergies too! Find out if Benadryl is a safe treatment.

There’s nothing quite like sad puppy eyes to tug at the heartstrings. Said puppy eyes cause even more stress if they are caused by something more than just desire for that piece of cheese you’re munching on! Our furry friends are everything to us, and when they clearly aren’t feeling their best, it’s natural to want to help them feel better fast.

But what if the doggie medicine cabinet is bare, and all you have is that bottle of Benadryl you keep for allergies? Is there a safe Benadryl dosage for dogs? Or should you steer clear? Let’s sniff out the facts about how much Benadryl is safe for a dog.

What is Benadryl?

Benadryl is a well-known brand of antihistamine medication used, primarily in humans, to tackle allergies, insomnia, anxiety, and motion sickness. It comes in various forms like tablets, capsules, topicals, and liquids.

How Does Benadryl Work?

  1. The active ingredient in Benadryl, diphenhydramine, blocks the action of histamine, a chemical that triggers allergy symptoms.
    a. Histamine binds to different receptors in the body, causing the blood vessels to dilate and become more permeable.
    b. This, in turn, may cause swelling, inflammation, increased heart rate, anxiety, and overstimulation of the respiratory tract, resulting in your dog sneezing, coughing, and having trouble breathing.
  2. Benadryl swoops in and binds to these receptors first, preventing histamine from wreaking havoc.

What Does Benadryl do for Dogs?

When dosed correctly (more on that below), Benadryl can address a range of conditions in dogs.

Most commonly, it is used to treat dog allergies, where it helps alleviate allergy symptoms such as your dog’s itching, sneezing, and scratching. (Side note: if your pup continues to suffer from itchy skin conditions, it might not be allergies – skin yeast infections are more common than you think, and easily and safely treated with Banixx Pet Care Spray.)

Possible side effects of Benadryl for dogsIts ability to slow the heart rate and promote a sense of calm – making it feel easier to breathe – means it can also be a key ally in treating motion sickness, anxiety, and insomnia in dogs.

Of course, as with any medication you give your dog, before reaching for the Benadryl it’s crucial to consult your vet for the correct dosage and frequency, specifically tailored to your dog’s size, breed and needs.

Is it Safe for Dogs?

Generally, Benadryl is safe for dogs when administered correctly. But caution, and correct dosage, is key.

The Benadryl dosage for dogs typically depends on your dog’s weight, with the usual range falling between 1-2 mg per pound every 8-12 hours. For example, if your pooch weighs 25 pounds, you’d give them 1 to 2 pills (25mg each) every 8-12 hours. However, it’s wise to start with a lower dose to gauge your dog’s reaction and watch closely for any adverse effects.

Ultimately, Benadryl can be a paw-some option for mild to moderate allergy-type symptoms that don’t require heavy-duty treatment. For more serious conditions or severe symptoms, however, a different medication might be necessary. Regardless, it’s always a good idea to bark up your vet’s tree for guidance!

Banixx Pet Care Spray: one solution for many problems!


Jane DeMeulemester

Jane DeMeulemester is co-owner of Banixx. Jane and her husband Robert own and operate the business in Pinehurst, NC. Jane is in charge of the Digital Marketing Department which includes multiple blog posts about the health and wellbeing of dogs, cats and horses. Jane and Robert own a farm in nearby Southern Pines which houses multiple cats, dogs and horses In her spare time she trains and competes her two horses in the discipline of Eventing.
Banixx has been making top quality, non-toxic pet-care products since 2006. All Banixx products are produced in the USA and bottled using only American-made components. Chosen by Horse Journal as the “Top Product Of The Year,” Banixx products fight infections associated with wounds, fungus, rain rot, ringworm, hot spots, dog ear infections, scratches (mud fever), abscesses, thrush, white line disease, bacterial and fungal infections, and secondary infections from bug bites and itches. Banixx is recommended by Veterinarians as a top-quality, affordable product. It’s available online or in your favorite feed or chain store. To learn more, visit

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